Agresta, Laura; Lehn, Maria; Lampe, Kristin; Cantrell, Rachel; Hennies, Cassandra; Szabo, Sara; Wise-Draper, Trisha; Conforti, Laura; Hoebe, Kasper; Janssen, Edith M 2020. CD244 represents a new therapeutic target in head and neck squamous cell carcinoma. Journal for immunotherapy of cancer, 8 1,
Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura 2020. A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11 , 143
Dirar, Qassim; Russell, Teal; Liu, Lumei; Ahn, Sarah; Dotti, Gianpietro; Aravamudhan, Shyam; Conforti, Laura; Yun, Yeoheung 2020. Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces. PloS one, 15 9, e0238819
Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura 2020. Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. Science advances, 6 47,
Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura 2020. PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for immunotherapy of cancer, 8 2,
Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura 2018. A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 527,
Rossi, Francesca; Geiszler, Philippine C; Meng, Weina; Barron, Matthew R; Prior, Malcolm; Herd-Smith, Anna; Loreto, Andrea; Lopez, Maria Yanez; Faas, Henryk; Pardon, Marie-Christine; Conforti, Laura 2018. NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural brain research, 339 , 140-152
Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura 2017. Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 1, 53-61
Conforti, Laura 2017. Potassium channels of T lymphocytes take center stage in the fight against cancer. Journal for immunotherapy of cancer, 5 , 2
Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura 2016. Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. Journal of autoimmunity, 69 , 86-93
Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura 2015. The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. Molecular biology of the cell, 26 9, 1640-51
Chimote, A. A.; Hajdu, P.; Kucher, V.; Boiko, N.; Kuras, Z.; Szilagyi, O.; Yun, Y. H.; Conforti, L. 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells , 191 12 , 6273-80
Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura 2013. Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. Journal of immunology (Baltimore, Md. : 1950), 191 12, 6273-80
Hajdu, Péter; Chimote, Ameet A.; Thompson, Tyler H.; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity Biomaterials, 34 38 , 10249-10257
Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura 2013. Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials, 34 38, 10249-57
Chimote AA, Kuras Z, Conforti, L 2012. Disruption of Kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes The Journal of Biological Chemistry, 287 3, 2055-2067
Conforti, Laura 2012. The ion channel network in T lymphocytes, a target for immunotherapy. Clinical immunology (Orlando, Fla.), 142 2, 105-6
Kuras Z, Kucher V, Gordon SM, Neumeier L, Chimote AA, Filipovich AH, Conforti L 2012. Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated via the Disc large 1 (Dlg1)-tyrosine kinase Lck complex American Journal of Physiology. Cell Physiology, 302 10, C1504-1512
Kuras, Z.; Yun, Y. H.; Chimote, A. A.; Neumeier, L.; Conforti, L. 2012. KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells PLoS ONE, 7 8 , e43859
Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura 2012. KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PloS one, 7 8, e43859
Li HC, Kucher V, Li EY, Conforti L, Zahedi K, Soleimani M 2012. The role of aspartic acid residues 405 and 416 of the kidney isotype of sodium-bicarbonate cotransporter 1 in its targeting to the plasma membrane American Journal of Physiology. Cell Physiology, 302 12, C1713-1730
Martin GV, Yun YH, Conforti L 2012. Modulation of T cell activation by localized K+ accumulation at the immunological synapse--a mathematical model Journal of Theoretical Biology, 300 , 173-182
Nicolaou SA, Neumeier L, Takimoto K, Lee SM, Duncan HJ, Kant SK, Mongey AB, Filipovich AH, Conforti L 2010. Differential calcium signaling and Kv1.3 trafficking to the immunological synapse in systemic lupus erythematosus Cell Calcium, 47 1, 19-28
Nicolaou SA, Neumeier L, Steckly A, Kucher V, Takimoto K, Conforti L 2009. Kv1.3 localization in the immunological synapse regulates the calcium response to antigen stimulation in T lymphocytes J Immunol, 183 10, 6296-6302
Nyakeriga AM, Fichtenbaum CJ, Goebel J, Nicolaou S, Conforti L, Chougnet C 2009. Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells: implications for T-cell activation during human immunodeficiency virus type 1 infection Journal of Virology, 83 3, 1193-1200
Li H, Li E, Neumeier L, Conforti L, Soleimani M 2007. Identification of a novel signal in the cytoplasmic tail of the Na+:HCO3- cotransporter NBC1 that mediates basolateral targeting American Journal of Physiology. Renal Physiology, 292 4, F1245-55
Nicolaou SA, Neumeier L, Peng Y, Devor D, Conforti L 2007. The Ca²+-activated K+ channel KCa3.1 compartmentalizes in the immunological synapse of human t lymphocytes Am J Physiol - Cell Physiol, 292 4, C1431-C1439
Nicolaou SA, Szigligeti P, Duncan HJ, Neumeier L, Lee SM, Mongey AB, Kant SK, Filipovich AH, Conforti L. 2007. Altered dynamics of Kv1.3 channel compartmentalization in the immunological synapse in systemic lupus erythematosus Journal of Immunology (Baltimore, Md. : 1950), 179 1, 346-356
Nicolaou, Stella A; Neumeier, Lisa; Peng, Youqing; Devor, Daniel C; Conforti, Laura 2007. The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. American journal of physiology. Cell physiology, 292 4, C1431-9
Szigligeti P, Neumeier L, Duke E, Chougnet C, Takimoto K, Molleran Lee S, Filipovich AH, Conforti L 2006. Signaling during hypoxia in human T lymphocytes - critical role of the src proteing tyrosine kinase p56lck in the oxygen-sensitivity of Kv1.3 channels Journal of Physiology, 573 2, 357-370
Szigligeti, Peter; Neumeier, Lisa; Duke, Eugene; Chougnet, Claire; Takimoto, Koichi; Lee, Susan Molleran; Filipovich, Alexandra H; Conforti, Laura 2006. Signalling during hypoxia in human T lymphocytes--critical role of the src protein tyrosine kinase p56Lck in the O2 sensitivity of Kv1.3 channels. The Journal of physiology, 573 Pt 2, 357-70
Li HC, Szigligeti P, Worrell R, Matthews J, Conforti L, Soleimani, M 2005. Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis American Journal of Physiology - Renal Physiology, 289 1, F61-71
Robbins JR, Lee SM, Filipovich AH, Szigligeti P, Neumeier L, Petrovic, Conforti, L 2005. Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels The Journal of Physiology, 564 Pt 1, 131-143
Zakrzewska A, Schnell PO, Striet JB, Hui A, Petrovic M, Robbins JR, Conforti L, Gozal D, Wathelet M, Czyzyk-Krzeska M 2005. Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and cbp in oxygen-sensitive cells Journal of Neurochemistry, 94 5, 1288-1296
Li HC, Worrell RT, Matthews JB, Husseinzadeh H, Neumeier L, Petrovic S, Conforti L, Soleimani M 2004. Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane The Journal of Biological Chemistry, 279 41, 43190-43197
Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. Slc26a7: a basolateral cl-/hco3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology - Renal Physiology, 286 1 , F161-F169
Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M 2004. SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct American Journal of Physiology. Renal Physiology, 286 1, F161-169
Sutliff RL, Conforti L, Weber CS, Kranias EG, Paul RJ 2004. Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse Vascular Pharmacology, 41 6, 197-204
Conforti L, Petrovic M, Mohammad D, Lee S, Ma Q, Barone S, Filipovich, Alexandra AH 2003. Hypoxia regulates expression and activity of Kv1.3 channels in T lymphocytes: a possible role in T cell proliferation Journal of Immunology (Baltimore, Md. : 1950), 170 2, 695-702
Conforti L, Takimoto K, Petrovic M, Pongs O, Millhorn D 2003. The pore region of the Kv1.2alpha subunit is an important component of recombinant Kv1.2 channel oxygen sensitivity. Biochemical and Biophysical Research Communications, 306 2, 450-456
Sievers, Caroline; Platt, Nick; Perry, V Hugh; Coleman, Michael P; Conforti, Laura 2003. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neuroscience research, 46 2, 161-9
Xu Jie, Wang Z, Barone S, Petrovic M, Amlal H, Conforti L, Petrovic S, Soleimani M 2003. Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant American Journal of Physiology. Renal Physiology, 284 1, F41-50
Takimoto K, Yang E-K, Conforti L 2002. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels Journal of Biological Chemistry, 277 30, 26904-26911
Thorne GD, Conforti L, Paul RJ 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca2+ channels American Journal of Physiology - Heart and Circulatory Physiology, 283 1 52-1, H247-H253
Thorne, George D; Conforti, Laura; Paul, Richard J 2002. Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels. American journal of physiology. Heart and circulatory physiology, 283 1, H247-53
Wang Z, Conforti L, Petrovic S, Amlal H, Burnham CE, Soleimani M 2001. Mouse Na+:HCO3- cotransporter isoform NBC-3 (kNBC-3): cloning, expression, and renal distribution Kidney International, 59 4, 1405-1414
Conforti L, Bodi I, Nisbet J W, Millhorn DE 2000. O2-sensitive K+ channels: role of the Kv1.2 alpha subunit in mediating the hypoxic response The Journal of Physiology, 524 3, 783-793
Conforti L, Millhorn DE 2000. Regulation of Shaker-type potassium channels by hypoxia Advances in Experimental Medicine and Biology, 475 , 265-274
Kobayashi S, Conforti L, Millhorn DE 2000. Gene expression and function of adenosine A2A receptors in the rat carotid body American Journal of Physiology - Lung Cellular and Molecular Physiology, 279 2, L273-282
Millhorn D, Beitner-Johnson D, Conforti L, Conrad P, Kobayashi S, Yuan Y, Rust R 2000. Gene Regulation During Hypoxia in Excitable Oxygen-Sensing Cells: Depolarization-Transcription Coupling Advances in Experimental Medicine and Biology, , 131-142
Conforti L, Kobayashi S, Beitner-Johnson D, Conrad PW, Freeman T, Millhorn DE 1999. Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells Respiration Physiology, 115 2, 249-260
Kobayashi S, Conforti L, Zhu WH, Beitner-Johnson D, Millhorn DE 1999. Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells Pflugers Archiv European Journal of Physiology, 438 6, 750-759
Kobayashi S, Beitner-Johnson D, Conforti L, Millhorn DE 1998. Chronic hypoxia reduces adenosine A2A receptor-mediated inhibition of calcium current in rat PC12 cells via downregulation of protein kinase A The Journal of Physiology, 512 ( Pt 2) , 351-363
Peng M, Conforti L, Millhorn DE 1998. Expression of somatostatin receptor genes and acetylcholine receptor development in rat skeletal muscle during postnatal development International Journal of Molecular Medicine, 1 5, 841-848
Conforti L, Millhorn DE 1997. Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia The Journal of Physiology, 502 2, 293-305
Kobayashi S, Conforti L, Pun RY, Millhorn DE 1997. Adenosine modulates hypoxic chemoreception in PC12 cells via A2 receptor stimulation The Journal of Physiology, 508 1, 95-107
Millhorn DE, Raymond R, Conforti L, Zhu W, Beitner-Johnson D, Filisko T, Genter MB, Kobayashi S, Peng M 1997. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia Kidney International, 51 2, 527-35
Zhu WH, Conforti L, Millhorn DE 1997. Expression of dopamine D2 receptor in PC-12 cells and regulation of membrane conductances by dopamine American Journal of Physiology - Cell Physiology, 273 42, C1143-C1150
Millhorn DE, Conforti L, Beitner-Johnson D, Zhu W, Raymond R, Filisko T, Kobayashi S, Peng M, Genter MB 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line Advances in Experimental Medicine and Biology, 410 , 135-42
Zhu WH, Conforti L, Czyzyk-Krzeska MF, Millhorn DE 1996. Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current American Journal of Physiology - Cell Physiology, 271 40, C658-665
Conforti L, Sumii K, Sperelakis N 1995. Dioctanoyl-glycerol inhibits l-type calcium current in embryonic chick cardiomyocytes independent of protein kinase c activation Journal of Molecular and Cellular Cardiology, 27 5, 1219-1224
Conforti L, Sumii K, Sperelakis N 1994. Diphenylamine-2-carboxylate blocks voltage-dependent na+ and ca2+ channels in rat ventricular cardiomyocytes European Journal of Pharmacology, 259 2, 215-218
Conforti L, Tohse N, Sperelakis N 1993. Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytes - contribution to the plateau phase of action potential Journal of Molecular and Cellular Cardiology, 25 2, 159-173
Cox D, Conforti L, Sperelakis N, Matlib M 1993. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157 Journal of Cardiovascular Pharmacology, 21 4, 595-599
Conforti L, Tohse N, Sperelakis N 1991. Influence of sympathetic innervation on the membrane electrical properties of neonatal rat cardiomyocytes in culture Journal of Developmental Physiology, 15 4, 237-246
Tohse N, Conforti L, Sperelakis N 1991. Bay K 8644 enhances Ca2+ channel activities in embryonic chick heart cells without prolongation of open times European Journal of Pharmacology, 203 2, 307-10
GEPC, Latini R, Tognoni G., Conforti L, Gondoni L, Santoro E, Rocchetti M 1988. Multicentre, cross sectional study of ventricular arrhythmias in chronically haemodialysed patients Lancet, 8606 , 305-307
Latini R, Zuanetti G, Conforti L, Schwartz PJ, Lazzara R 1988. Demonstration of a different sensitivity to epinephrine in isolated and in vivo hearts European Journal of Pharmacology, 156 1, 87-94
Chen Z, Colombo T, Conforti L, Donelli M, Fiedorowicz RJ, Marchi S, Paolini A, Riva E, Zuanetti G, Latini R 1987. Effects of three new anthracyclines and doxorubicin on the rat isolated heart The Journal of Pharmacy and Pharmacology, 39 11, 947-950
Caccia S, Conforti L, Conti I 1986. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat Journal of Pharmacy and Pharmacology, 38 6, 469-472